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Search Result

Search Results for " ad 1 "

71

Compounds

8

Natural Products

1756

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T39678 Multitarget AD inhibitor-1
Multitarget AD inhibitor-1 is a reversible and selective inhibitor of butyrylcholinesterase (BuChE) with IC50 values of 7.22 μM and 1.55 μM for human BuChE (hBuChE) and equine serum BuChE (eqBuChE), respectively. Additio...
T60150 (1S,2R)-Alicapistat Cysteine Protease
(1S,2R)-Alicapistat ((1S,2R)-ABT-957) is a highly efficient, orally active compound that selectively inhibits human calpains 1 and 2, with promising implications for Alzheimer's disease (AD) therapy [1]. This compound ef...
T77042 Aducanumab BIIB037 Beta Amyloid
Aducanumab (BIIB037), A selective human immunoglobulin gamma-1 (IgG1) monoclonal antibody, targets the clustered form of amyloid beta (Aβ). Aducanumab shows brain permeability and may be used to treat Alzheimer's disease...
T80622 Trontinemab
Trontinemab, a bispecific humanized IgG1-κ antibody, targets the amyloid beta A4 precursor protein (APP) and transferrin receptor p90, CD71 (TFRC). It is utilized in research on Alzheimer's disease (AD) [1] [2].
T4364 Aftin-4 Aftin 4,Aftin4 Beta Amyloid , Gamma-secretase
Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4(Aftin4) increased Aβ-1-42, but not Aβ-1-40 in mouse hipppocampus...
T11175 Elenbecestat E2609 Beta-Secretase , BACE
Elenbecestat (E2609) is an effective oral bioutilization and CNS penetrating ACE-1 inhibitor for the treatment of Alzheimer's disease.
TP1930L1 Spexin acetate(1370290-58-6 free base) Neuropeptide Y Receptor
Spexin acetate is a potent galanin receptor 2/3 (GAL2/GAL3) agonist (EC50 values are 45.7 and 112.2 nM, respectively). Exhibits no significant activity at galanin receptor 1. Endogenous satiety-inducing peptide; inhibits...
T76738 Bapineuzumab
Bapineuzumab, an anti-β-amyloid protein (APP) monoclonal antibody, is utilized in Alzheimer’s disease (AD) research [1].
T14178 Alicapistat ABT-957 Others
Alicapistat (ABT-957) is a human calpains 1 and 2 inhibitor. It can potentially be used to treat Alzheimer's disease (AD).
T32330 JWB1-84-1 3HCl JWB1 84 1 3HCl,JWB1 84 1 trihydrochloride,JWB1-84-1 trihydrochloride,JWB1841 trihydrochloride
JWB1-84-1 3HCl, as a neuroprotective agent, can act by improving cognitive performances in a transgenic mouse model of AD.
T80878 Vanutide cridificar PF 05236806,ACC-001
Vanutide cridificar (ACC-001) is an aminoterminal Aβ1-7 peptide conjugate, employed in Alzheimer’s disease (AD) research [1].
T78807 YIAD-0205
YIAD-0205, an orally administered inhibitor of Aβ(1-42) aggregation, has exhibited in vivo efficacy in a 5XFAD transgenic mouse model that harbors five familial AD mutations [1].
T76926 Bepranemab
Bepranemab (UCB 0107), a humanized full-length IgG4 monoclonal antibody, targets the central tau epitope (amino acids 235-250) and is utilized in Alzheimer’s disease (AD) research [1].
T79752 DDC 2′,3′-O-disulfate
DDC 2′,3′-O-disulfate (compound 4) inhibits the fibrillization and oligomerization of Aβ42, showing promise for Alzheimer's disease (AD) research [1].
T78333 Rocatinlimab AMG 451,KHK4083
Rocatinlimab (AMG 451) (KHK4083) is a fully human, non-fucosylated IgG1 anti-OX40 monoclonal antibody indicated for atopic dermatitis (AD) research [1].
T76816 Lokivetmab
Lokivetmab, an Anti-Canine IL31 Recombinant Antibody, is a monoclonal antibody targeting canine IL-31, utilized in research related to atopic dermatitis (AD) in dogs [1].
T35892 Q134R Q134R
Q134R, a neuroprotective derivative of hydroxyquinoline, effectively inhibits nuclear factor of activated T-cell (NFAT) signaling and possesses the ability to cross the blood-brain barrier. This compound shows promise fo...
T79010 Lp-PLA2-IN-12 Phospholipase
Lp-PLA2-IN-12 (compound 19), an Lp-PLA2 inhibitor, is utilized in researching neurodegenerative diseases including Alzheimer's disease (AD), glaucoma, age-related macular degeneration (AMD), and cardiovascular conditions...
T80700 β Amyloid(17-28) human
β-Amyloid(17-28) human is a fragment of the β-amyloid peptide (Abeta) associated with Alzheimer's disease (AD), promoting the aggregation of the full-length β-Amyloid40 into toxic aggregates [1]. This lipid-induced amylo...
T62578 BuChE-IN-1
BuChE-IN-1 (Compound 23) is a potent, highly blood-brain barrier-permeable, low cytotoxicity inhibitor of butyrylcholinesterase (BuChE). BuChE-IN-1 is a BuChE inhibitor that has the potential to be used in the study of A...
T61408 BChE-IN-2
BChE-IN-2 (compound 22) is a highly effective inhibitor of BChE, exhibiting a Ki value of 0.099 μM. This compound represents a promising pyrimidine and pyridine derivative for investigating Alzheimer's disease (AD). [1]
T79011 TrkB-IN-1 Trk receptor
TrkB-IN-1 is a potent, orally active agonist of the TrkB receptor, with favorable pharmacokinetic (PK) properties. It has been shown to reverse cognitive deficits in an Alzheimer's disease (AD) mouse model, thus serving ...
T64181 SEH/AChE-IN-1
sEH/AChE-IN-1 (Compound 12a) is a dual inhibitor of soluble epoxide hydrolase (sEH) and acetylcholinesterase (AChE). sEH/AChE-IN-1 has a cumulative effect against neuroinflammation and memory impairment. sEH/AChE-IN-1 ha...
T64214 NXPZ-2
NXPZ-2 is an orally active Keap1-Nrf2protein-protein interaction (PPI) inhibitor (Ki: 95 nM, EC50: 120 and 170 nM). NXPZ-2 dose-dependently attenuates Aβ[1-42]-induced cognitive disturbances, enhances neuronal number and...
T75930 β-Amyloid (1-43)(human) TFA
β-Amyloid (1-43)(human) TFA exhibits greater aggregation tendencies and heightened toxicity compared to its well-established counterpart, Aβ1-42. Additionally, this compound demonstrates associations with both sAPPα and ...
T77028 Gosuranemab
Gosuranemab (BMS-986168), a humanized IgG4 anti-tau monoclonal antibody, specifically targets human N-terminal tau residues 15-22. It holds potential for Alzheimer’s disease (AD) research [1] [2].
T76395 (Met(O)35)-Amyloid β-Protein (1-42)
(Met(O)35)-Amyloid β-Protein (1-42) represents the oxidized form of Methionine 35 in Aβ42, capable of producing an oligomer size distribution akin to that of Aβ40. This compound is utilized in Alzheimer’s disease (AD) re...
T62719 AChE/BACE1/GSK3β-IN-1
AChE/BACE1/GSK3β-IN-1 is an orally active, blood-brain barrier-transparent, moderately bioavailable triple inhibitor of AChE/BACE1/GSK3β. AChE/BACE1/GSK3β-IN-1 can be used to study Alzheimer's disease (AD).
T60739 Y13g
Y13g is the potent inhibitor of Interleukin-6 (IL-6) and acetylcholinesterase(AChE) which are two important targets implicated in Alzheimer's Disease(AD) progression. Y13g reverses the memory deficit induced by STZ as we...
TP1228 β-Amyloid (1-16) Amyloid β-Protein (1-16),β-Amyloid 1-16
β-Amyloid (1-16) is an amyloidogenic protein fragment with a sequence derived from β-amyloid. It exhibits the ability to bind to metal ions, indicating its involvement in metal-binding processes. β-Amyloid, a peptide, is...
T78874 GSK-3β inhibitor 15
GSK-3β inhibitor 15 (Compound 54), with an IC50 of 3.4 nM, effectively suppresses Aβ 1-42-induced phosphorylation of GSK-3β and tau protein, as well as LPS-induced iNOS expression. It demonstrates neuroprotective propert...
T79684 5-HT6R antagonist 1 5-HT Receptor
Compound 8 (5-HT6R antagonist 1), a 5-HT6R antagonist (K i : 5 nM), not only demonstrates inhibition of platelet aggregation and excellent metabolic stability but also reverses MK-801-induced memory impairments in rats, ...
T79548 AChE/BChE-IN-13
AChE/BChE-IN-13 (compound 5j) serves as a potent dual inhibitor of both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), exhibiting half-maximal inhibitory concentrations (IC50) of 20.89 μM for AChE and 17.3...
T79533 PDE5-IN-10
PDE5-IN-10 (compound 4b), a potent phosphodiesterase type 5 (PDE5) inhibitor, exhibits an effective half-maximal inhibitory concentration (IC50) of 20 nM, enhanced in vitro microsomal stability (t 1/2 = 44.6 min), and ex...
T61388 HAChE/Aβ1-42-IN-1
Compound 16 (hAChE/Aβ1-42-IN-1) is a potent inhibitor targeting both hAChE and Aβ1-42 aggregation, demonstrating considerable safety in hepG2 cell lines and excellent brain-blood barrier (BBB) penetration with a broad sa...
T76372 TRAF6 peptide
TRAF6 peptide, a specific TRAF6-p62 inhibitor, effectively inhibits NGF-dependent TrkA ubiquitination, showcasing strong research potential for neurological conditions including Alzheimer's disease (AD), Parkinson's, ALS...
T80118 α-Synuclein (61-95) (human)
α-Synuclein (61-95) (human) constitutes the hydrophobic core of α-synuclein and is implicated in inducing neuronal cell death. This segment is utilized in the study of neurodegenerative conditions such as Alzheimer's dis...
T61342 BChE-IN-13
BChE-IN-13 (Compound 17c) is an orally active, potent, and selective inhibitor of Butyrylcholinesterase (BChE). It exhibits IC50 values of 0.22 μM and 0.016 μM for eqBChE and hBChE, respectively. BChE-IN-13 demonstrates ...
T61785 BChE-IN-6
BChE-IN-6 (compound 12) is a highly effective inhibitor of BChE, showcasing a Ki value of 0.182 μM. Notably, BChE-IN-6 exhibits significant chelating abilities towards Zn 2+. Due to these characteristics, BChE-IN-6 serve...
T78221 TRAF6 peptide TFA E1/E2/E3 Enzyme
TRAF6 peptide TFA, a specific inhibitor of the TRAF6-p62 interaction, significantly inhibits NGF-dependent ubiquitination of TrkA. This peptide demonstrates promising research applications in various neurological disorde...
T74818 JNK3 inhibitor-8
JNK3 Inhibitor-8 is a potent, selective, and orally active inhibitor that can cross the blood-brain barrier, targeting JNK3 with IC50 values of 21 nM for JNK3, 2203 nM for JNK2, and >10000 nM for JNK1. This compound demo...
T38002 LEO 39652
LEO 39652, a dual-soft PDE4 inhibitor, demonstrates potent inhibition of PDE4 subtypes A, B, C, and D with respective IC50 values of 1.2 nM, 1.2 nM, 3.0 nM, and 3.8 nM. Additionally, it inhibits TNF-α with an IC50 of 6.0...
T61087 THK-5105
THK-5105, an arylquinoline derivative, demonstrates a high binding affinity for tau fibrils, protein aggregates, and tau-rich Alzheimer's disease (AD) brain homogenates, indicative of its potential as a tau imaging PET (...
T76394 Cys-Gly-Lys-Lys-Gly-Amyloid β-Protein (36-42)
Amyloid β-Protein (36-42), the 36-42 fragment of β-Amyloid, consists of a polypeptide chain of 36-43 amino acids and is a primary constituent of amyloid plaques in Alzheimer's disease (AD) patients' brains. β-Amyloid oli...
T78596 CAD031
CAD031, a more active derivative of the Alzheimer's disease (AD) targeting agent J147, exhibits neuroprotective and memory-enhancing properties. It has been shown to enhance memory, improve dendritic structure, and stimu...
T82242 HAChE-IN-6
hAChE-IN-6 (compound 51) is a brain-penetrant acetylcholinesterase (AChE) inhibitor exhibiting an IC50 of 0.16 μM. It also demonstrates inhibitory effects on human butyrylcholinesterase (hBuChE) and glycogen synthase kin...
T75730 [D-Arg25]-Neuropeptide Y (human)
[D-Arg25]-Neuropeptide Y (human) ([D-Arg25] NPY), a Y1 receptor selective agonist, plays a role in Alzheimer's disease (AD) and safeguards rat cortical neurons from β-Amyloid toxicity [1].
T60907 THK-5117
THK-5117 is an arylquinoline derivative with the potential as a PET probe for tau imaging. THK-5117 shows high binding affinity to tau fibrils with a Ki value of 10.5 nM. THK-5117 also shows high binding affinity to tau ...
T76221 Leptin (116-130)
Leptin (116-130), a bioactive fragment of leptin, enhances synaptic plasticity in the hippocampus by promoting AMPA receptor trafficking to synapses. It preserves hippocampal synapse integrity and prevents neuronal cell ...
T37148 TML-6
TML-6, an oral curcumin derivative, demonstrates inhibitory effects on the synthesis of β-amyloid precursor protein and β-amyloid (Aβ). Additionally, TML-6 exhibits upregulation of Apo E, suppression of NF-κB and mTOR, a...

Compounds

Multitarget AD inhibitor-1
T39678
Synonym:
Target:
(1S,2R)-Alicapistat
T60150
Synonym:
Target: Cysteine Protease
Aducanumab
T77042
Synonym: BIIB037
Target: Beta Amyloid
Trontinemab
T80622
Synonym:
Target:
Aftin-4
T4364
Synonym: Aftin 4,Aftin4
Target: Beta Amyloid, Gamma-secretase
Elenbecestat
T11175
Synonym: E2609
Target: Beta-Secretase, BACE
Spexin acetate(1370290-58-6 free base)
TP1930L1
Synonym:
Target: Neuropeptide Y Receptor
Bapineuzumab
T76738
Synonym:
Target:
Alicapistat
T14178
Synonym: ABT-957
Target: Others
JWB1-84-1 3HCl
T32330
Synonym: JWB1 84 1 3HCl,JWB1 84 1 trihydrochloride,JWB1-84-1 trihydrochloride,JWB1841 trihydrochloride
Target:
Vanutide cridificar
T80878
Synonym: PF 05236806,ACC-001
Target:
YIAD-0205
T78807
Synonym:
Target:
Bepranemab
T76926
Synonym:
Target:
DDC 2′,3′-O-disulfate
T79752
Synonym:
Target:
Rocatinlimab
T78333
Synonym: AMG 451,KHK4083
Target:
Lokivetmab
T76816
Synonym:
Target:
Q134R
T35892
Synonym: Q134R
Target:
Lp-PLA2-IN-12
T79010
Synonym:
Target: Phospholipase
β Amyloid(17-28) human
T80700
Synonym:
Target:
BuChE-IN-1
T62578
Synonym:
Target:
BChE-IN-2
T61408
Synonym:
Target:
TrkB-IN-1
T79011
Synonym:
Target: Trk receptor
sEH/AChE-IN-1
T64181
Synonym:
Target:
NXPZ-2
T64214
Synonym:
Target:
β-Amyloid (1-43)(human) TFA
T75930
Synonym:
Target:
Gosuranemab
T77028
Synonym:
Target:
(Met(O)35)-Amyloid β-Protein (1-42)
T76395
Synonym:
Target:
AChE/BACE1/GSK3β-IN-1
T62719
Synonym:
Target:
Y13g
T60739
Synonym:
Target:
β-Amyloid (1-16)
TP1228
Synonym: Amyloid β-Protein (1-16),β-Amyloid 1-16
Target:
GSK-3β inhibitor 15
T78874
Synonym:
Target:
5-HT6R antagonist 1
T79684
Synonym:
Target: 5-HT Receptor
AChE/BChE-IN-13
T79548
Synonym:
Target:
PDE5-IN-10
T79533
Synonym:
Target:
hAChE/Aβ1-42-IN-1
T61388
Synonym:
Target:
TRAF6 peptide
T76372
Synonym:
Target:
α-Synuclein (61-95) (human)
T80118
Synonym:
Target:
BChE-IN-13
T61342
Synonym:
Target:
BChE-IN-6
T61785
Synonym:
Target:
TRAF6 peptide TFA
T78221
Synonym:
Target: E1/E2/E3 Enzyme
JNK3 inhibitor-8
T74818
Synonym:
Target:
LEO 39652
T38002
Synonym:
Target:
THK-5105
T61087
Synonym:
Target:
Cys-Gly-Lys-Lys-Gly-Amyloid β-Protein (36-42)
T76394
Synonym:
Target:
CAD031
T78596
Synonym:
Target:
hAChE-IN-6
T82242
Synonym:
Target:
[D-Arg25]-Neuropeptide Y (human)
T75730
Synonym:
Target:
THK-5117
T60907
Synonym:
Target:
Leptin (116-130)
T76221
Synonym:
Target:
TML-6
T37148
Synonym:
Target:
1 2
Cat No. Product Name Synonyms Targets
T6S0721 Orientin Lutexin,Luteolin-8-glucoside Others
1. Orientin (Luteolin-8-glucoside) may be regarded as a candidate therapeutic agent for treatment of vascular inflammatory diseases via inhibition of the HMGB1 signaling pathway. 2. Orientin protects vascular barrier int...
TN3218 7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one Beta Amyloid , PI3K , mTOR
7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one as a beneficial compound to ameliorate the deleterious effects of Aβ on dendrite integrity and cell survival, and may provide new insights on drug discovery of Alzheimer's dise...
T75544 AChE/BChE-IN-11
AChE/BChE-IN-11 (compound 1), a natural product derived from artichoke leaves, is a dual inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50 values of 70 μM for AChE and 71 μM for BChE, re...
T75511 BChE-IN-10
BChE-IN-10 (compound 6), isolated from Bletilla striata, is a potent mixed-type butyrylcholinesterase (BChE) inhibitor exhibiting an IC50 value of 6.4 μM. It is utilized in Alzheimer's disease (AD) research [1].
T75512 Bleformin A
Bleformin A, a natural product isolated from Bletilla striata, serves as a potent butyrylcholinesterase (BChE) inhibitor, exhibiting an IC50 value of 5.2 μM. It is utilized in Alzheimer's disease (AD) research [1].
T75514 Blestrin D
Blestrin D, a potent mixed-type butyrylcholinesterase (BChE) inhibitor with an IC50 value of 8.1 μM, is isolated from Bletilla striata and has applications in Alzheimer's disease (AD) research [1].
T75513 BChE-IN-12
BChE-IN-12, also known as compound 12, is a potent non-competitive inhibitor of butyrylcholinesterase (BChE) with an IC50 value of 2.3 μM. Derived from Bletilla striata, it is utilised in research related to Alzheimer's ...
T75628 Methyl ganoderate A acetonide
Methyl ganoderate A acetonide, a lanostane triterpene derived from the fruiting bodies of Ganoderma lucidum, serves as a potent acetylcholinesterase (AChE) inhibitor with an IC50 value of 18.35 μM. Its efficacy in inhibi...

Natural Products

Orientin
T6S0721
Synonym: Lutexin,Luteolin-8-glucoside
Target: Others
7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one
TN3218
Synonym:
Target: Beta Amyloid, PI3K, mTOR
AChE/BChE-IN-11
T75544
Synonym:
Target:
BChE-IN-10
T75511
Synonym:
Target:
Bleformin A
T75512
Synonym:
Target:
Blestrin D
T75514
Synonym:
Target:
BChE-IN-12
T75513
Synonym:
Target:
Methyl ganoderate A acetonide
T75628
Synonym:
Target:

Recombinant Proteins

Species：
Human (1435)
Mouse (234)
Rat (26)
Cynomolgus (25)
Chinese hamster (4)
RSV (4)
Human (3)
Phleum pratense (3)
Human,Cynomolgus,Rhesus (2)
Human,Cynomolgus,Rhesus macaque (2)
Expression System：
HEK293 (1325)
E. coli (209)
Baculovirus-Insect Cells (189)
CHO (14)
Yeast (10)
Human Cells (9)
Tag：
His (708)
hFc (229)
C-His-Avi (181)
Tag Free (107)
C-His (95)
His,GST (74)
C-hFc (54)
GST (40)
mFc (40)
His,AVI (39)
Cat No. Product Name Species Expression System
TMPY-01284 METTL11A Protein, Human, Recombinant (GST) Human E. coli
Methyltransferase-like protein 11A, also known as METTL11A, is a member of the methyltransferase superfamily and METTL11 family. Methyltransferase is a type of transferase enzyme which transfers a methyl group from a don...
TMPY-04770 RIOK1 Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
RIOK1, also known as RIO kinase 1, is a member of the RIO family of atypical serine protein kinases first characterized in yeast. RIOK1 and RIOK2 proteins are present in organisms from Archaea to humans. RIOK1 functions ...
TMPY-01285 METTL11A Protein, Human, Recombinant Human E. coli
Methyltransferase-like protein 11A, also known as METTL11A, is a member of the methyltransferase superfamily and METTL11 family. Methyltransferase is a type of transferase enzyme which transfers a methyl group from a don...
TMPY-01479 SPG3A Protein, Human, Recombinant (GST) Human Baculovirus-Insect Cells
Atlastin-1, also known as Spastic paraplegia 3 protein A, Guanine nucleotide-binding protein 3, GTP-binding protein 3, GBP3, ATL1 and SPG3A, is a multi-pass membrane protein which belongs to theGBP family and atlastin...
TMPJ-00023 SNCA Protein, Human, Recombinant (His) Human E. coli
Alpha-Synuclein (SNCA) is a member of the Synuclein family. SNCA is expressed principally in brain but also expressed in low concentrations in all tissues except liver. SNCA interacts with UCHL1, Phospholipase D and hist...
TMPY-00668 APP/Protease nexin-II Protein, Human, Recombinant (hFc) Human HEK293
Amyloid precursor protein (APP) is a type I transmembrane protein expressed in many tissues and concentrated in the synapses of neurons, and is suggested as a regulator of synapse formation and neural plasticity. APP can...
TMPY-02110 Beta-amyloid 40/Beta-APP40 Protein, Human, Recombinant (His & GST) Human E. coli
Amyloid precursor protein (APP) is a type I transmembrane protein expressed in many tissues and concentrated in the synapses of neurons, and is suggested as a regulator of synapse formation and neural plasticity. APP can...
TMPY-02221 Beta-amyloid 42/Beta-APP42 Protein, Human, Recombinant (His & GST) Human E. coli
Amyloid precursor protein (APP) is a type I transmembrane protein expressed in many tissues and concentrated in the synapses of neurons, and is suggested as a regulator of synapse formation and neural plasticity. APP can...
TMPY-03884 Beta-amyloid 39/Beta-APP39 Protein, Human, Recombinant (aa 672-710, His & GST) Human E. coli
Amyloid precursor protein (APP) is a type I transmembrane protein expressed in many tissues and concentrated in the synapses of neurons, and is suggested as a regulator of synapse formation and neural plasticity. APP can...
TMPY-03885 Beta-amyloid 38/Beta-APP38 Protein, Human, Recombinant (aa 672-709, His & GST) Human E. coli
Amyloid precursor protein (APP) is a type I transmembrane protein expressed in many tissues and concentrated in the synapses of neurons, and is suggested as a regulator of synapse formation and neural plasticity. APP can...
TMPY-01253 LAMP1 Protein, Human, Recombinant (His) Human HEK293
Lysosome-associated membrane glycoprotein 1, also known as CD107 antigen-like family member A, CD107a, and LAMP1, is a single-pass type I membrane protein that belongs to the LAMP family. CD107a is expressed largely in t...
TMPH-02996 KsdD Protein, Mycobacterium smegmatis, Recombinant (His & Myc) Mycolicibacterium smegmatis E. coli
Catalyzes the elimination of the C-1 and C-2 hydrogen atoms of the A-ring from the polycyclic ring structure of 3-ketosteroids. Is also involved in the formation of 1,4-androstadiene-3,17-dione (ADD) from 4-androstene-3,...
TMPJ-00782 Amyloid Precursor Protein, Human, Recombinant (hFc) Human Human Cells
Amyloid precursor protein (APP) is a type I membrane protein with several isoforms due to alternative splicing, performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and...
TMPY-01303 Serpin A3 Protein, Human, Recombinant (His) Human HEK293
SerpinA3, also known as Alpha 1-antichymotrypsin (AACT), is a plasma alpha globulin glycoprotein, and is a member of serpin superfamily of the serine protease inhibitors consisting of at least 35 members. SerpinA3 has be...
TMPY-02916 LAMP1 Protein, Rat, Recombinant (hFc) Rat HEK293
Lysosome-associated membrane glycoprotein 1, also known as CD107 antigen-like family member A, CD107a, and LAMP1, is a single-pass type I membrane protein that belongs to the LAMP family. CD107a is expressed largely in t...
TMPY-03653 CTRL Protein, Human, Recombinant (His) Human HEK293
CTRL-1, also known as chymotrypsin-like protease, belongs to thepeptidase S1 family. CTRL-1 contains 1peptidase S1 domain. Its expression is increased in preeclampsia (PE). Placental-derived chymotrypsin-like protease is...
TMPY-02393 Thimet Oligopeptidase/THOP1 Protein, Mouse, Recombinant (His) Mouse Baculovirus-Insect Cells
THOP1, also known as Thimet oligopeptidase 1, Thimet oligopeptidase, EC 3.4.24.15, or EP24.15, is a zinc(II) endopeptidase implicated in the processing of numerous physiological peptides. As an intracellular enzyme, high...
TMPY-00519 Gastrokine 1 Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
Gastrokine 1 (GKN1) belongs to the BRICHOS domain family and plays a major role in maintaining gastric mucosa integrity. GKN1 is highly expressed in gastric tissue and is secreted into the stomach but is not expressed in...
TMPY-02300 BIN1 Protein, Human, Recombinant (His) Human E. coli
Amphiphysin 2, also named bridging integrator-1 (BIN1) or SH3P9, Amphiphysin2/BIN1 is a crescent-shaped N-BAR protein playing a key role in forming deeply invaginated tubes in muscle T-tubules, has been recently implicat...
TMPY-01297 Nicastrin Protein, Human, Recombinant (His) Human HEK293
Nicastrin (NCST, or NCT), a single-pass membrane glycoprotein that harbors a large extracellular domain, is an essential component of the gamma-secretase complex. Several lines of evidence indicate that the members of th...
TMPY-01221 Nogo Receptor/RTN4R Protein, Mouse, Recombinant (His & hFc) Mouse HEK293
Reticulon 4 receptor (RTN4R), also known as Nogo-66 Receptor (NgR), is a glycosylphosphoinositol (GPI)-anchored protein that belongs to the Nogo recptor family including three members. Mouse RTN4R cDNA contains 1 LRP (Le...
TMPY-01056 Nogo Receptor/RTN4R Protein, Human, Recombinant (His & hFc) Human HEK293
Reticulon 4 receptor (RTN4R), also known as Nogo-66 Receptor (NgR), is a glycosylphosphoinositol (GPI)-anchored protein that belongs to the Nogo recptor family including three members. Mouse RTN4R cDNA contains 1 LRP (Le...
TMPY-03144 Nogo Receptor/RTN4R Protein, Human, Recombinant (His) Human HEK293
Reticulon 4 receptor (RTN4R), also known as Nogo-66 Receptor (NgR), is a glycosylphosphoinositol (GPI)-anchored protein that belongs to the Nogo recptor family including three members. Mouse RTN4R cDNA contains 1 LRP (Le...
TMPY-01163 Nogo Receptor/RTN4R Protein, Mouse, Recombinant (His) Mouse HEK293
Reticulon 4 receptor (RTN4R), also known as Nogo-66 Receptor (NgR), is a glycosylphosphoinositol (GPI)-anchored protein that belongs to the Nogo recptor family including three members. Mouse RTN4R cDNA contains 1 LRP (Le...
TMPY-02910 Nicastrin Protein, Mouse, Recombinant (His) Mouse HEK293
Nicastrin (NCST, or NCT), a single-pass membrane glycoprotein that harbors a large extracellular domain, is an essential component of the gamma-secretase complex. Several lines of evidence indicate that the members of th...
TMPY-03074 Nicastrin Protein, Mouse, Recombinant (hFc) Mouse HEK293
Nicastrin (NCST, or NCT), a single-pass membrane glycoprotein that harbors a large extracellular domain, is an essential component of the gamma-secretase complex. Several lines of evidence indicate that the members of th...
TMPY-01233 LRPAP1 Protein, Human, Recombinant (His) Human HEK293
Receptor-associated protein (RAP) is a molecular chaperone for low-density lipoprotein receptor-related protein (LRP), which plays a key role in cholesterol metabolism. The lipoprotein receptor-related protein (LRP) is a...
TMPY-04451 AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST) is expressed in Baculovirus-Insect Cells
TMPY-01732 LRPAP1 Protein, Mouse, Recombinant (His) Mouse HEK293
Receptor-associated protein (RAP) is a molecular chaperone for low-density lipoprotein receptor-related protein (LRP), which plays a key role in cholesterol metabolism. The lipoprotein receptor-related protein (LRP) is a...
TMPY-03878 Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His) Human HEK293
Integrin alpha-5, also known as ITGA5, is a single-pass type I membrane protein which belongs to the integrin alpha chain family. ITGA5 contains 7 FG-GAP repeats. Alpha chain 5 undergoes post-translational cleavage in th...
TMPY-02501 CD3D & CD3E Heterodimer Protein, Human, Recombinant Human HEK293
CD3D & CD3E Heterodimer Protein, Human, Recombinant is expressed in HEK293 cells.
TMPY-03745 CD3D & CD3E Heterodimer Protein, Human, Recombinant (Flag & His) Human HEK293
CD3D & CD3E Heterodimer Protein, Human, Recombinant (Flag & His) is expressed in HEK293 with Flag and His tag. The predicted molecular weight is 31.05 kDa. Accession number: P04234-1&P07766-1
TMPY-02794 TLR2 Protein, Human, Recombinant (aa 1-587, His) Human Baculovirus-Insect Cells
TLR2, also known as CD282, is a member of the Toll-like receptor (TLR) family. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They play a fundamental role in pathoge...
TMPY-03947 CD48 Protein, Human, Recombinant (hFc) Human HEK293
Cluster of Differentiation 48 (CD48), also known as SLAMF2, BCM-1 and BLAST-1, is a GPI-linked protein belonging to the CD2 subfamily of immunoglobulin superfamily molecules. CD2 and 2B4 (CD244) are known ligands for CD4...
TMPY-03481 IL-1R2 Protein, Human, Recombinant Human HEK293
Interleukin 1 receptor, type II (IL1R2) also known as CD121b (Cluster of Differentiation 121b) is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein binds interleukin alpha (IL1A), interl...
TMPK-00114 C-Reactive Protein /CRP Protein, Human, Recombinant (His) Human HEK293
C-reactive protein (CRP) is a polypeptide molecule belonging to the family of pentraxins. CRP is synthesized primarily by the liver in response to certain pro-inflammatory cytokines. It plays an important role in innate ...
TMPY-00740 SDF-1 Protein, Human, Recombinant (hFc) Human HEK293
The human stromal cell-derived factor-1 (SDF1), also known as CXCL12, is a small (8 kDa) cytokine highly conserved chemotactic cytokine belonging to the large family of CXC chemokines. SDF1 is expressed in two isoforms f...
TMPY-04384 Src Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
Proto-oncogene tyrosine-protein kinase SRC is a hydrophobic protein belonging to the SRC family kinase including nine members that is a family of non-receptor tyrosine kinases. SRC protein may exist in different forms: C...
TMPK-01151 MXRA8 Protein, Human, Recombinant (His) Human HEK293
Mxra8 is a recently described receptor for multiple alphaviruses, including Chikungunya (CHIKV), Mayaro (MAYV), Ross River (RRV), and O'nyong nyong (ONNV) viruses.
TMPK-01074 CD163 Protein, Human, Recombinant (His & Avi) Human HEK293
The hemoglobin (Hb) scavenger receptor, CD163, is a macrophage-specific protein and the upregulated expression of this receptor is one of the major changes in the macrophage switch to alternative activated phenotypes in ...
TMPK-00383 ACE2/ACEH Protein, Human, Recombinant (His & Avi) Human HEK293
ACE2 (Angiotensin I Converting Enzyme 2) is a Protein Coding gene. Diseases associated with ACE2 include Severe Acute Respiratory Syndrome and Neurogenic Hypertension.The protein encoded by this gene belongs to the angio...
TMPY-02525 RGMA Protein, Human, Recombinant (His) Human HEK293
RGMa, also known as RGM domain family, member A, belongs to the RGM (repulsive guidance molecule) family whose members are membrane-associated glycoprotein. RGMa is a glycosylphosphatidylinositol-anchored glycoprotein th...
TMPY-04753 IRE1 Protein, Human, Recombinant (aa 465-977) Human Baculovirus-Insect Cells
Endoplasmic reticulum stress and hypoxia are necessary components of malignant tumors growth and suppression of ERN1 (from endoplasmic reticulum to nuclei-1) signalling pathway, which is linked to the apoptosis and cell ...
TMPY-04413 IRE1 Protein, Human, Recombinant (aa 465-977, His & GST) Human Baculovirus-Insect Cells
Endoplasmic reticulum stress and hypoxia are necessary components of malignant tumors growth and suppression of ERN1 (from endoplasmic reticulum to nuclei-1) signalling pathway, which is linked to the apoptosis and cell ...
TMPK-01393 Tenascin Protein, Mouse, Recombinant (His) Mouse HEK293
Tenascin-C (TNC) is a hexameric, multimodular extracellular matrix protein with several molecular forms that are created through alternative splicing and protein modifications. It is highly conserved amongst vertebrates,...
TMPK-00305 TGFBR1 Protein, Human, Recombinant (mFc & Avi) Human HEK293
transforming growth factor beta receptor 1 (TGFBR1), a key stimulator of tumor proliferation and metastasis, was a direct target of miR‑98‑5p. miR‑98‑5p overexpression resulted in the downregulation of TGFBR1 and the sup...
TMPY-01460 ABHD4 Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
Abhydrolase domain containing 4 (ABHD4), also known as alpha/beta-hydrolase 4 (ABH4) , or lyso-N-acylphosphatidylethanolamine lipase, which belongs to the ABHD4/ABHD5 subfamily of peptidase S33 family. Abhydrolase domain...
TMPY-00978 Progranulin Protein, Human, Recombinant (His) Human HEK293
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The precursor protein, progranulin, ...
TMPY-02227 IL-1 beta/IL-1F2 Protein, Rat, Recombinant (mature form) Rat E. coli
Interleukin-1 beta (IL1 beta or IL1B) also known as catabolin, is a member of the interleukin 1 cytokine family. IL1 is a pleiotropic cytokine. It is involved in the inflammatory response, cell growth, and tissue repair ...
TMPY-05526 Siglec-15 Protein, Human, Recombinant (His) Human HEK293
Siglec-15 Protein, Human, Recombinant (His) is expressed in HEK293 cells.
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METTL11A Protein, Human, Recombinant (GST)
TMPY-01284
Species: Human
Expression System: E. coli
RIOK1 Protein, Human, Recombinant (His & GST)
TMPY-04770
Species: Human
Expression System: Baculovirus-Insect Cells
METTL11A Protein, Human, Recombinant
TMPY-01285
Species: Human
Expression System: E. coli
SPG3A Protein, Human, Recombinant (GST)
TMPY-01479
Species: Human
Expression System: Baculovirus-Insect Cells
SNCA Protein, Human, Recombinant (His)
TMPJ-00023
Species: Human
Expression System: E. coli
APP/Protease nexin-II Protein, Human, Recombinant (hFc)
TMPY-00668
Species: Human
Expression System: HEK293
Beta-amyloid 40/Beta-APP40 Protein, Human, Recombinant (His & GST)
TMPY-02110
Species: Human
Expression System: E. coli
Beta-amyloid 42/Beta-APP42 Protein, Human, Recombinant (His & GST)
TMPY-02221
Species: Human
Expression System: E. coli
Beta-amyloid 39/Beta-APP39 Protein, Human, Recombinant (aa 672-710, His & GST)
TMPY-03884
Species: Human
Expression System: E. coli
Beta-amyloid 38/Beta-APP38 Protein, Human, Recombinant (aa 672-709, His & GST)
TMPY-03885
Species: Human
Expression System: E. coli
LAMP1 Protein, Human, Recombinant (His)
TMPY-01253
Species: Human
Expression System: HEK293
KsdD Protein, Mycobacterium smegmatis, Recombinant (His & Myc)
TMPH-02996
Species: Mycolicibacterium smegmatis
Expression System: E. coli
Amyloid Precursor Protein, Human, Recombinant (hFc)
TMPJ-00782
Species: Human
Expression System: Human Cells
Serpin A3 Protein, Human, Recombinant (His)
TMPY-01303
Species: Human
Expression System: HEK293
LAMP1 Protein, Rat, Recombinant (hFc)
TMPY-02916
Species: Rat
Expression System: HEK293
CTRL Protein, Human, Recombinant (His)
TMPY-03653
Species: Human
Expression System: HEK293
Thimet Oligopeptidase/THOP1 Protein, Mouse, Recombinant (His)
TMPY-02393
Species: Mouse
Expression System: Baculovirus-Insect Cells
Gastrokine 1 Protein, Human, Recombinant (His)
TMPY-00519
Species: Human
Expression System: Baculovirus-Insect Cells
BIN1 Protein, Human, Recombinant (His)
TMPY-02300
Species: Human
Expression System: E. coli
Nicastrin Protein, Human, Recombinant (His)
TMPY-01297
Species: Human
Expression System: HEK293
Nogo Receptor/RTN4R Protein, Mouse, Recombinant (His & hFc)
TMPY-01221
Species: Mouse
Expression System: HEK293
Nogo Receptor/RTN4R Protein, Human, Recombinant (His & hFc)
TMPY-01056
Species: Human
Expression System: HEK293
Nogo Receptor/RTN4R Protein, Human, Recombinant (His)
TMPY-03144
Species: Human
Expression System: HEK293
Nogo Receptor/RTN4R Protein, Mouse, Recombinant (His)
TMPY-01163
Species: Mouse
Expression System: HEK293
Nicastrin Protein, Mouse, Recombinant (His)
TMPY-02910
Species: Mouse
Expression System: HEK293
Nicastrin Protein, Mouse, Recombinant (hFc)
TMPY-03074
Species: Mouse
Expression System: HEK293
LRPAP1 Protein, Human, Recombinant (His)
TMPY-01233
Species: Human
Expression System: HEK293
AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST)
TMPY-04451
Species: Human
Expression System: Baculovirus-Insect Cells
LRPAP1 Protein, Mouse, Recombinant (His)
TMPY-01732
Species: Mouse
Expression System: HEK293
Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His)
TMPY-03878
Species: Human
Expression System: HEK293
CD3D & CD3E Heterodimer Protein, Human, Recombinant
TMPY-02501
Species: Human
Expression System: HEK293
CD3D & CD3E Heterodimer Protein, Human, Recombinant (Flag & His)
TMPY-03745
Species: Human
Expression System: HEK293
TLR2 Protein, Human, Recombinant (aa 1-587, His)
TMPY-02794
Species: Human
Expression System: Baculovirus-Insect Cells
CD48 Protein, Human, Recombinant (hFc)
TMPY-03947
Species: Human
Expression System: HEK293
IL-1R2 Protein, Human, Recombinant
TMPY-03481
Species: Human
Expression System: HEK293
C-Reactive Protein /CRP Protein, Human, Recombinant (His)
TMPK-00114
Species: Human
Expression System: HEK293
SDF-1 Protein, Human, Recombinant (hFc)
TMPY-00740
Species: Human
Expression System: HEK293
Src Protein, Human, Recombinant (His & GST)
TMPY-04384
Species: Human
Expression System: Baculovirus-Insect Cells
MXRA8 Protein, Human, Recombinant (His)
TMPK-01151
Species: Human
Expression System: HEK293
CD163 Protein, Human, Recombinant (His & Avi)
TMPK-01074
Species: Human
Expression System: HEK293
ACE2/ACEH Protein, Human, Recombinant (His & Avi)
TMPK-00383
Species: Human
Expression System: HEK293
RGMA Protein, Human, Recombinant (His)
TMPY-02525
Species: Human
Expression System: HEK293
IRE1 Protein, Human, Recombinant (aa 465-977)
TMPY-04753
Species: Human
Expression System: Baculovirus-Insect Cells
IRE1 Protein, Human, Recombinant (aa 465-977, His & GST)
TMPY-04413
Species: Human
Expression System: Baculovirus-Insect Cells
Tenascin Protein, Mouse, Recombinant (His)
TMPK-01393
Species: Mouse
Expression System: HEK293
TGFBR1 Protein, Human, Recombinant (mFc & Avi)
TMPK-00305
Species: Human
Expression System: HEK293
ABHD4 Protein, Human, Recombinant (His)
TMPY-01460
Species: Human
Expression System: Baculovirus-Insect Cells
Progranulin Protein, Human, Recombinant (His)
TMPY-00978
Species: Human
Expression System: HEK293
IL-1 beta/IL-1F2 Protein, Rat, Recombinant (mature form)
TMPY-02227
Species: Rat
Expression System: E. coli
Siglec-15 Protein, Human, Recombinant (His)
TMPY-05526
Species: Human
Expression System: HEK293
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Cat No. Product Name
L9840 Anti-Alzheimer's Disease Compound Library

986 compounds
A unique collection of 986 compounds with anti-AD activities or acting on main drug targets of AD can be used for HTS and HCS.

Libraries

Anti-Alzheimer's Disease Compound Library
L9840
Compounds: 986
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